Research on the role of social media use in the workplace has gained more interest, yet little is known about personal characteristics that might influence the outcomes that employees experience when they use social media during work. This research aims to investigate the impact of the intensity of social media use at work on three aspects of burnout: emotional exhaustion, depersonalization, and lack of personal accomplishment. Results from partial least squares regression found that mindfulness significantly mediated the relationship between the intensity of social media use at work on emotional exhaustion and lack of personal accomplishment. These findings suggest that using social media during work tends to increase burnout in employees who have a low level of mindfulness, but it lowers burnout in employees who have a high level of mindfulness.