Osteoporosis is the most common metabolic bone disease. In this experimental study, 120 patients (60 experimental and 60 control) from women aged 30 to 50 years old, who were registered under the health centers in Fasa City, Fars Province, Iran, were selected. After intervention, the experimental group showed a significant increase in the health belief model constructs, self-regulation, social support, and nutrition and walking performance compared to the control group. After 6 months of intervention, the value of lumbar spine and hip bone mineral density T-score in the experimental group increased, while in the control group it reduced. This study showed the effectiveness of health belief model and structures of self-regulation and social support in prevention of osteoporosis in women.