Objective: To review the challenges and potential benefits of involving adolescents in the development and delivery of prevention programming. Key Points and Implications: Adolescent violence prevention programs are typically designed and delivered by adults in school-based settings. However, research has highlighted a number of problems with the effectiveness and sustainability of adult-designed prevention models. In this commentary, we consider the possibility that program effectiveness might be improved if innovative, evidence-based prevention strategies could be developed to help guide adolescents in developing and delivering prevention materials themselves. To inform our discussion, we surveyed 14 adolescent peer leaders about their experiences developing and delivering violence prevention in their schools and communities. Using their input, we critically review the limitations of adult-delivered prevention, discuss the potential benefits and challenges of involving adolescents in designing and delivering violence prevention content, and suggest a number of future directions for researchers and program developers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)