Research Summary In this article, we outline the potential ways that genetic research can be used to inform the development, testing, and dissemination of preventative interventions. We conclude by drawing attention to how the incorporation of genetic variables into prevention designs could help identify individual variability in program effectiveness and thereby increase program success rates. Policy Implications Evidence‐based prevention science seeking to reduce crime and other related behavioral disorders has made significant progress in the identification of risk factors involved in the development of antisocial behavior, as well as in the creation and testing of such programs intended to target these risk factors. Nonetheless, issues of program effectiveness remain as individual responsivity to prevention interventions is often overlooked. Paralleling the movement toward evidence‐based prevention science, but largely isolated from such efforts, has been an area of research devoted toward identifying how genetic factors interact with social environments to influence behavioral outcomes. By joining these two fields, genetically informed prevention interventions have the potential to increase our understanding of the causes of crime and other problem behaviors, as well as to help identify individual variability in program effectiveness.