After briefly surveying three generations of comparative sociologists, interdisciplinary regional and trans-regional studies are shown to complement the work of the third generation of comparative sociologists on civilizational analysis and multiple modernities. Drawing examples from the interdisciplinary Persianate studies, promoted by the Association for the Study of Persianate Societies in the last two decades, and by other recent interdisciplinary studies of performance and world literature as well as Caribbean regional studies, it is argued that the rise of interdisciplinary studies in social sciences and humanities may in fact redeem the unfulfilled promise that comparative sociology once offered. These recent studies constitute a significant contribution to our theoretical understanding of different patterns of socio-cultural development beyond the West, whose historical experience gave birth to modern social science disciplines, and thereby to register the historical experience of a very sizeable portion of humankind as the basis for the reconstruction of social theory in the global age.