This article connects existing mobility biographies research with social practice inquiries into the dynamics of consumption and examines the potential of a biographic, practice-centred approach for researching everyday practices. Following a critical review of the benefits and limitations of existing research on mobility biographies, the article explores some key ways in which a practice theory approach can be employed to reframe and extend how dynamics of mobility over the life course can be conceptualised and analysed. A key feature of the discussion is a consideration of the ways in which the concepts of practice and career can broaden investigations of practice biographies to include various perspectives and scales. The article then outlines the development and application of a biographic, practice-centred methodology which was employed in an ongoing mobility biographies study based in Ireland. In demonstrating the potential of this approach for researching practice careers across the life course, empirical data relating to an individual’s career-in-car-driving are presented and discussed. The article concludes that, despite some limitations, practice-centred biographic approaches offer potential for addressing some unanswered questions regarding mobility practices.