For many Black adolescents, racial discrimination increases the risk of developing adverse psychological outcomes. The purpose of this study is to investigate the interrelationships among religious involvement, racial discrimination, and psychological outcomes among a nationally representative sample of African American adolescents and Caribbean Black adolescents from the National Survey of American Life. Multiple regression models were used to determine the interactive effects of religious involvement and racial discrimination experiences on Black adolescents’ psychological outcomes. Findings indicate that religious involvement was a protective factor for Caribbean Black adolescents but not African American youth. The implications of these findings underscore the varied roles of religious involvement for African American and Caribbean Black adolescents.