Purpose: This study systematically examined previous studies on the effect of early ambulation on vascular complications in subjects who had just undergone a percutaneous coronary intervention (PCI), and analyzed the effects of early ambulation on both hemorrhage and hematoma formation at the puncture site.

Methods: Study data were analyzed using the R (version 2.13.1) program. Publication bias was verified via regression analysis, using the logarithm of the odds ratio (OR) and sample size, and a funnel plot using sample size. The risk ratio of the incidence of bleeding and hematoma formation at the puncture site, relative to early ambulation, was confirmed using ORs and the forest plot.

Results: The PCI recipients’ bed rest time had no significant effect on the risk ratio of hematoma formation (OR = 0.89; 95% CI = 0.68–1.17) nor the incidence of bleeding (OR = 1.14; 95% CI = 0.77–1.7) at the puncture site.

Conclusions: This retrospective study’s findings show that early ambulation following PCI had no effect on the incidence of either hematoma formation nor bleeding at the puncture site; however, differences in demographic factors should be considered carefully, in order to avoid interpreting the results too broadly.