This study examined the role of acculturation to the host culture, acculturation to the home culture, and dispositional hope in career decision self-efficacy (CDSE) in a sample of 213 Korean international undergraduate students enrolled in U.S. universities. The findings revealed that hope and acculturation to the host culture uniquely and positively predicted CDSE. Acculturation to the home culture was positively related to CDSE but did not account for unique variance in CDSE beyond that accounted for by hope. Hope was the strongest predictor of CDSE. As expected, acculturation to the host culture and acculturation to the home culture were not significantly related, suggesting that one does not necessarily require sacrifice of the other. No interaction effects were found between hope and acculturation variables on CDSE. Limitations of this study and implications for future research and practice are discussed.