It is increasingly common to test hypotheses combining moderation and mediation. Structural equation modeling (SEM) has been the favored approach to testing mediation hypotheses. However, the biggest challenge to testing moderation hypotheses in SEM was the complexity underlying the modeling of latent variable interactions. We discuss the latent moderated structural equation procedure (LMS) approach to specifying latent variable interactions, which is implemented in Mplus, and offer a simple and accessible way of testing combined moderation and mediation hypotheses using SEM. To do so, we provide sample code for six commonly encountered moderation and mediation cases and relevant equations that can be easily adapted to researchers’ data. By articulating the similarities in the two different approaches, discussing the combination of moderation and mediation, we also contribute to the research methods literature.