College waterpipe tobacco smokers who feel more ambivalence, that is, conflicted about its use, may have a stronger desire to quit. Using baseline survey data of 315 college waterpipe smokers, we examined this relationship. While frequency of feeling ambivalence was low, greater ambivalence was related with desire to quit (r = .46, p < .001). This relationship remained significant after accounting for several correlates of desire to quit (e.g. perceived risk and worries about harm and addiction). Findings suggest that ambivalence may be an important independent variable linked with desire to quit and should be explored further as a factor influencing waterpipe tobacco use.