With the dramatic recent changes in Chinese society, Chinese college students’ average levels of loneliness and social support might also have changed across their birth cohorts. The present cross-temporal meta-analysis of 56 studies (N = 21,541) found that Chinese college students’ scores on the UCLA Loneliness Scale (Version 3) increased gradually from 2002 to 2011. The increasing trend in loneliness occurred among both men and women. Another similar meta-analysis of 110 studies (N = 57,420) showed that Chinese college students’ scores on the Social Support Rating Scale decreased from 1999 to 2011, with a slightly larger shift occurring among college men. The increase in loneliness across birth cohorts among Chinese college students was associated with the decline of their perceived social support levels (especially objective social support).