This study examined the influence of different mood states on Creative Science Problem Finding (CSPF). CSPF was measured in terms of Fluency, Flexibility, and Originality. Imagery techniques were used to induce positive or negative mood states in participants, with results suggesting that positive mood led to a significant increase in CSPF performance compared with neutral mood, especially for the dimensions of fluency and flexibility. No difference was found between negative mood and neutral mood. Results provide evidence that anger had no impact on CSPF performance compared with neutral mood. However, fear appeared to inhibit the performance of CSPF. The interaction between specific moods and CSPF provide evidence that moods influenced CSPF with open instructions more than with closed instructions.