Does income inequality increase political backlash against European and global integration? This paper reports research suggesting that it can. The article analyses party opposition to and support for trade openness, European Union integration and general internationalism of political party platforms in advanced industrial democracies between 1960 and 2008. It finds that inequality tends to increase anti-globalization positions of parties, net of pro-globalization positions, an effect that does not significantly differ across party families or levels of actual globalization. This effect, however, does depend on, and is diminished by, generous redistributive policies. These findings clarify socio-economic conditions underlying the backlash against political and economic globalization.