Endogenous growth policy and partnership collaboration have become increasingly prevalent in the search for value creation and innovation in regional development. Little attention is, however, paid to the dynamic role of project leadership in promoting such broad partnership-based collaboration. Drawing on experiences and data from a partnership-based Regional Development Coalition in Norway (2007–2010), this inquiry seeks to fill this gap. It explores, from a project leadership viewpoint, key challenges in orchestrating and facilitating bottom-up learning processes along the horizontal dimension, and the upholding of national mandates and political visions along the vertical dimension. Based on the empirical findings, a model is developed which sheds light on the complex role of project leadership in partnership-based collaborations.