This article focuses on one expression of the relationship between science and policy analysis: the Office of Information and Regulatory Affairs (OIRA) in the Office of Management and Budget. It has used a classic policy analysis technique—cost–benefit analysis—as the way that the White House will review regulations. This discussion highlights the utilization of the cost–benefit method in the OIRA decision-making process, the roles of various actors in the system, and the response to that use by various policy actors. It illustrates the difficulty of utilizing rational analytical methods in an environment of political conflict.