Mindfulness has emerged as an important factor that assists people in regulating difficult emotions, but it is not yet known whether mindfulness plays a role in supportive communication. The current study examines whether mindfulness facets (describing, observing, nonjudging, aware acting, nonreacting) positively influence self-reported abilities to (a) discern more and less person-centered (PC) supportive messages and (b) facilitate reappraisals via two core cognitive factors, namely, empathy and active listening. College students with little or no meditation experience (N = 183) completed an online survey. Mediation analyses showed that empathy and active listening partially mediated the relationship between two mindfulness facets (describing, observing) and the two perceptual outcome measures (PC message discriminations, facilitating reappraisals) by accounting for 33% and 62% of the variance. Additional structural equation modeling suggested that mindful observing and describing positively predicted empathy and active listening. Both mindful describing and nonjudging also positively predicted facilitating reappraisals. Interestingly, nonjudging negatively predicted empathy and active listening. The results point to mindfulness as an important factor that influences cognitive-affective processes in supportive communication.