The study tested (a) the extent to which an inverted-U pattern of fear response predicted persuasion, (b) the degree to which the fear curve mediated the effects of the four components of threat appeals on persuasion, (c) the correspondence between the static measures of fear used in between-subjects designs and the dynamic indices required by the within-subject approach, and (d) the methodological threats inherent to dynamic designs. Participants (N = 418) read a message that advocated colorectal cancer screening. Results showed that the inverted-U fear curve predicted intention to obtain a colonoscopy, and that susceptibility and response efficacy exerted their influence on persuasion via the fear curve while severity and self-efficacy did not. The static measure of fear showed poor absolute correspondence with the peak and end indices of dynamic fear, but strong pattern correspondence. Hazards to inference posed by dynamic designs of the type used in this study appear negligible.