Building on work funded by the European Spatial Planning Observatory Network 2013 Program, the article analyzes the regional development of the "creative workforce" among its active population against regional economic growth measured by changes in per capita gross domestic product over the period 2001 to 2008. The analysis establishes regional typologies in this relationship according to the "sense" and evolution of this association, allowing a critical evaluation of processes and policies that may explain the large degree of spatial variation encountered, and addresses the issue of causal relationships between these two dimensions, suggesting the need to rethink development policies based on "creative capital."