This article investigates the effect of disability on progress in the start-up process. One person out of 10 has a disability, yet entrepreneurship literature remains silent on the contributions of this population. This is surprising given that people with disabilities are more likely to be self-employed than the general population. Results from the Panel Study of Entrepreneurial Dynamics show that start-up efforts by nascent entrepreneurs with disabilities are less likely to result in the emergence of a viable organization, indicating that nascent entrepreneurs with disabilities face particular challenges.