This article seeks to reflect on knowledge and experiences gained from an International Research Staff Exchange Scheme (IRSES). Challenges and opportunities inherent in the development and management of a large-scale international research project in social work are explored. Through a synthesis of conceptual frameworks a process model for international research collaboration is constructed based chiefly on the stages of group development, a conceptual framework for cross-national research, an interdisciplinary teamwork process and collaborative knowledge building. The five stages of the process model, namely forming, norming, storming, performing and adjourning and associated steps are connected by a practice of reflexivity.