The goal of the study was to explore the relationship between personality characteristics and the development of resilience in the context of social work. To do this, combining the transverse and longitudinal approaches, we investigated 479 students and professional social workers. For students, the within-subject analysis shows that this group, while pursuing a university degree, are reaching greater openness, accountability, extraversion and kindness and, by contrast, are reducing their levels of neuroticism, which is the personality trait that acquires smaller presence on the professional stage. The regression results also confirmed the influence and predictive ability of personality traits on the resilience of students and social workers.