This study investigates social workers’ preferences regarding four main therapeutic orientations: psychodynamic therapy (PDT), cognitive-behavioral therapy (CBT), client-centered therapy (CCT), and eco-systemic therapy (EST). In total, 679 social workers (528 Jewish and 151 Palestinian) reported their beliefs regarding the efficacy of the four therapeutic orientations, and 343 additional social workers (193 Jewish and 150 Palestinian) reported how often they apply the therapeutic orientations in their practice. The present study revealed similarities, but also some incongruence when comparing the social workers’ beliefs in the efficacy of the different therapeutic orientations and the frequency of their actual use in practice. Socio-demographic characteristics of the social workers explained a significant albeit small proportion of the variance in the frequency of use of the different therapeutic orientations. Finally, the results obtained demonstrated that social workers tend to prefer different therapeutic interventions when working with clients belonging to different ethnic groups. Implications for therapist training and practice are discussed.