The aim of this study was the validation of the Dutch version of the Middle Childhood Home Observation for Measurement of the Environment (MC-HOME), an interview and observation instrument to measure the quality and quantity of stimulation and support available to a child in the home environment. Participants in this cross-sectional study were 134 children from a generally low-risk sample of Dutch families. Children were between the ages 6 and 10 years, including 73 (54.5%) girls and 61 (45.5%) boys. Internal consistencies were low, but good interrater reliabilities were found. Significant associations between the MC-HOME and socioeconomic status, child behavior problems, and parental stress were found. Although the association with language scores was not statistically significant, it was in the expected direction. This study suggests that the MC-HOME is a valid screening instrument, though modernization and cultural adaptation of the instrument are desirable.