Growing research suggests that work–family conflict is harmful to individual well-being. However, few studies have examined this relationship among African Americans, as well as what cultural institutions and practices may help in dealing with the stress of work–family conflict. This study suggests that religion may be an important resource for African Americans in the face of work–family conflict. Using data from the National Survey of Religion and Family Life, a telephone survey of working-age U.S. adults, this study outlines a series of arguments linking work–family conflict, religious involvement, and life satisfaction among African Americans. The results suggest some support for religious involvement in moderating—or buffering—the harmful effects of work–family conflict on the life satisfaction of African Americans. Study limitations are identified and several promising directions for future research are discussed.