Using data from the National Longitudinal Transition Study–2 (NLTS2), this study examines the career and technical education (CTE) course taking of high school students with learning disabilities (LD) in the context of the national movement toward higher standards for determining whether students leave high school "college and career ready." Descriptive analyses document the extent of general education CTE course taking overall by students with LD and their engagement in a concentrated program of occupationally specific general education CTE, a level of course taking early research has linked to improved post–high school employment outcomes. Propensity score modeling was used to determine whether either type of CTE course taking is related to higher odds of full-time employment after high school and whether results differ with the length of time youth were out of high school. Results show no benefits of CTE course taking overall, but demonstrate a significant positive effect for participating in a concentration of occupationally specific CTE in the first 2 post–high school years; effects are nonsignificant for later years. The implications for high school programming and transition planning for students with LD are discussed.