Qualitative comparative analysis (QCA) was developed over 25 years ago to bridge the qualitative and quantitative research gap. On searching PubMed and the Journal of Mixed Methods Research, this review identified 30 original research studies that used QCA. Perceptions that QCA is complex and provides few relative advantages over other methods may be limiting QCA adoption. Thus, to overcome these perceptions, this article demonstrates how to perform QCA using data from 15 institutions that implemented universal tumor screening programs to identify patients at high risk for hereditary colorectal cancer. In this example, QCA revealed a combination of conditions unique to effective universal tumor screening programs. Results informed additional research and provided a model for improving patient follow-through after a positive screen.