Purpose: This was a descriptive–correlational study designed to determine factors associated with the healthy lifestyle behaviors of high school students in Turkey. Design: The study sample consisted of 812 high school adolescents. The Adolescent Lifestyle Profile scale was used to identify the healthy lifestyle behaviors of adolescents. Results: The total Adolescent Lifestyle Profile mean score of 2.75 ± 0.33 and the mean score on the Interpersonal relations subscale were found to be the highest scores while the mean score on the Health responsibility subscale was found to be the lowest. Significant predictors of healthy lifestyle behaviors of adolescents were good relationships with family and friends, having a father who was a college graduate, and good health perception. Conclusions: The study revealed similar results among adolescents of different cultures. Implications for Practice: These findings can be used as a guide in developing an adolescent health promotion program for school nurses.