Women’s philanthropy has drawn much attention during recent years, mostly in studies from the United States or the United Kingdom. Relevant issues are to what extent gender differences in charitable giving exist in another national context and how these differences can be explained. In this study, we examine female and male giving in the Netherlands, using a representative sample of Dutch households (N = 1,692) from the 2010 wave of the Giving in the Netherlands Panel Survey (GINPS). We conduct bivariate and multivariate regression analyses to test for gender differences and the extent to which they are mediated by values, costs, solicitation, and social pressure. Females turn out to be more likely to give and to give to more different sectors, which can be attributed to their higher prosocial values of empathic concern and the principle of care. Contrary to recent findings in the United States, Dutch males donate higher amounts than Dutch females.