Due to the politicization of much policymaking in the European Union (EU) policymaking and the growing competences of the European Parliament (EP), party groups in the EP have become key targets for organized interests. This article investigates which party groups in the EP are prioritized by EU lobbyists and why. The focus is on two presumed key components of this prioritization process, namely power and position. It is expected that lobbyists take into account both the extent to which parties align with their views and their legislative power. The empirical analysis draws on interviews with 143 interest group officials and their lobbying expenditures on 78 legislative proposals initiated by the European Commission between 2008 and 2010. The analysis suggests that the media prominence of party groups in relation to specific issues as well as the extent to which interest organizations and party groups adopt opposing policy positions considerably shape how party groups in the EP are targeted by lobbyists.