Nickel-based Inconel X-750 superalloy is widely applied in aerospace industry and manufacturing of gas turbine blades, power generators and heat exchangers due to its exclusive properties. As a consequence of low heat transfer coefficient and work-hardening properties, this alloy is known as a poorly machinable alloy. In this work, effect of machining parameters (cutting speed, feed rate and depth of cut) on cutting forces and surface roughness was investigated during turning of Inconel alloy X-750 with coated carbide tool. In order to meet the demands of the environment-friendly cutting processes and human health, biodegradable vegetable oil (BioCut 4600) was selected as the cutting fluid. The results were analyzed using response surface methodology and statistical analysis of variance, and mathematical models for cutting forces and surface roughness were proposed. Results indicated that feed rate and cutting speed were the most effective parameters on the surface roughness. However, depth of cut was the most effective parameter on cutting forces in comparison with cutting speed and feed rate. Eventually, in order to achieve the main aims of industrial production in large amounts and green manufacturing, the ranges for the best cutting conditions were presented.