Turn milling is one of the machining processes used to mill circular work pieces while the work piece rotates about its own axis. Orthogonal milling is one of the turn milling processes where the bottom part of cutter removes material from the rotating work piece with high metal removal rate. In this article, tool condition was studied by analyzing surface roughness and vibration of cutter with the use of response surface methodology. According to design of experiments, 16 experiments were conducted on ASTM B139 phosphor bronze with high-speed steel end mill cutter on four-axis milling machine. The response surface methodology was used to find out significant parameters that are affecting surface roughness and amplitude of cutter vibration. A multi-response optimization technique was used to identify optimum cutting parameters for less surface roughness and amplitude of cutter vibration.