Forced convection of water–Cu nanofluid in a two-dimensional microchannel is studied numerically. The microchannel wall is divided into three parts. The entry and exit ones are kept insulated while the middle one has more temperature than the inlet fluid. The whole of microchannel is under the influence of a magnetic field with uniform strength of B ₀. Slip velocity and temperature jump are involved along the microchannel walls for different values of slip coefficient such as B = 0.001, B = 0.01, and B = 0.1 for Re = 10, Re = 50, and Re = 100. Navier–Stokes equations are discretized and numerically solved by a developed computer code in FORTRAN. Results are presented as the velocity, temperature, and Nusselt number profiles. Moreover, the effect of magnetic field on slip velocity and temperature jump is investigated for the first time in the present work. Larger Hartmann number, Reynolds number, and volume fraction correspond to more heat transfer rate; however, the effects of Ha and are more significant at higher Re.