Inner wall profile of the cylinder in a rotary vane compressor (RVC), which influences the motion characteristics of vanes, suction volume, friction characteristic, etc., plays an important role in the performance of the compressor. This work mainly aims at the profile design of a new cylinder for a double-acting RVC with harmonic profile cylinder on the basis of not changing integrate size. According to the relation between cylinder profile and vane motion characteristics, a method for the cylinder profile design is proposed in this paper. With an assumed vane motion, equations of the cylinder profile, cell volume of the compressor as well as pressure angles between vanes and cylinder inner wall are constructed preliminarily. And then through adjusting parameters and optimization with an independently developed procedure, a new cylinder with the so-called combined profile is obtained. Theoretical analysis of the cell volume variations and the pressure angles between vanes and cylinder are conducted. The results show that there is neither rigid impulse nor soft impulse between vanes and cylinder due to the vane continuous motion including displacement, velocity and acceleration. And the pressure angles between vane and cylinder and working volume of the compressor with the new profile cylinder are superior to harmonic profile cylinder, which is useful for the reduction of friction power in the operation of compressor. Experiments show that the cooling capacity and COP of the test refrigeration cycle with the proposed combined profile cylinder is higher than the compressor with harmonic profile cylinder. And the volumetric efficiency and isentropic efficiency of the compressor with combined profile cylinder have better performance. This method can be applied to the design of the cylinder for multiple-acting rotary vane compressors, rotary vane expanders and vane pumps.