In this article, we outline methodological considerations for conducting research interviews with couples. We draw from two qualitative men’s health studies, both developed to explore social interactions between men and their partners of either sex in relation to their health practices. We utilized a combination of separate interviews and joint couple interviews. From these studies, we offer insight into our experiences of using both types of interview styles, addressing four key areas which span elements across the research project journey: (a) choosing a mode of interview, (b) ethical concerns in couple research, (c) the interview as a platform for disclosure, and (d) analyzing data from couple research.