This article describes an Indigenous and qualitative research project with 13 First Nation (FN) and Métis youth attending an Aboriginal youth health and wellness program located in the Canadian prairies. Our goal was to collaborate with the youth to co-create knowledge concerning their definitions of health using a convergence of Indigenous and qualitative methodologies. Independent but interconnected themes that emerged are discussed as related to neurodecolonization and the recovery of traditional practices and their contribution to youth resilience. The resilience of youth was reflected in these themes as well as their definitions of health. Our findings point to the importance of acknowledging and validating the role that neurodecolonization practices contribute to healing, both at individual and collective levels. Furthermore, we suggest recognizing resilience as well as viewing health holistically to more adequately understand and address the health-related concerns of FNs, Métis, and Inuit (FNMI) youth.