This article explores whether understanding of the effects of children’s problems on older parents’ well-being can be advanced by exploring differences in parent–child relationships within families. Using data from a study in which mothers reported on all adult children, we addressed the question: Do patterns of maternal favoritism moderate the impact of children’s problems on psychological well-being? Based on the literature on the effects of children’s problems and on parental favoritism, we hypothesized that problems in the lives of favored adult children will have a more detrimental impact than when they affect unfavored offspring. Results revealed strong and detrimental effects of any offspring’s problems on mothers’ well-being; these effects occurred, however, regardless of parental preference for an adult child. The findings suggest that the well-documented effects of parental preference may be limited in domains such as problems and difficult transitions in adult children’s lives.