Information and Communication Technologies (ICTs) are often proclaimed to facilitate the fragmentation of activities, a process whereby a certain activity is divided into several smaller pieces, which are performed at different times and/or locations. This study analyzes two-day combined activity, travel and communication diaries collected among Dutch households and presents quantitative findings of the associations between ICTs and the spatiotemporal fragmentation of paid labour. Controlling for various coping strategies, employment and commute factors, household characteristics, lifestyle orientation, time personality and spatial context, statistically significant relations were found between ICTs and the spatiotemporal fragmentation of paid labour for both men and women. The fact that both positive and negative associations were found suggests that ICTs can be adopted to make use of opportunities to arrange paid labour in a flexible way, or as a compensation when such opportunities are lacking. The results also indicate that up to a certain degree these associations are gender specific.