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Are inflammatory parameters predictors of amputation in acute arterial occlusions?

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Vascular

Published online on

Abstract

Background

The aim of the present study was to investigate the role of inflammatory markers to predict amputation following embolectomy in acute arterial occlusion.

Methods

A total of 123 patients operated for arterial thromboembolectomy due to acute embolism were included in the study. The patients without an extremity amputation following thromboembolectomy were classified as Group 1 (n = 91) and the rest were classified as Group 2 (n = 32). These groups were compared in terms of clinical and demographic characteristics, C-reactive protein, complete blood count parameters, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and red cell distribution width.

Results

The average age was 68.0 ± 11.7 years. The most common thromboembolism localization was femoral artery. When preoperative mean C-reactive protein (p = 0.0001), mean platelet volume (p = 0.0001), platelet-lymphocyte ratio (p = 0.0001), neutrophil-lymphocyte ratio (p = 0.0001) and red cell distribution width (p = 0.0001) were compared, a statistically significant difference was observed between groups. In univariate and multivariate regression analysis, higher levels of preoperative C-reactive protein (p = 0.009) and mean platelet volume (p = 0.04) were detected as independent risk factors of early extremity amputation.

Conclusion

We observed that preoperative mean platelet volume and C-reactive protein were predictors of amputation after thromboembolectomy in acute arterial occlusion.