This article examines the current knowledge shaping our understanding of human trafficking for the purposes of sexual exploitation in Australia, a major destination country in a poorly researched region (Oceania). Challenges to developing accurate and useful knowledge: varied and poorly understood definitions, difficulties in gathering accurate data about a hidden problem, and narrowly focused research are explored. The article describes Australia’s current responses to sex trafficking and critiques current knowledge development strategies, concluding with recommendations for ways forward in researching this challenging and globally significant problem.