This paper provides an overview of the development and current practice of physical anthropology as relating to the treatment of archaeological skeletal remains in Europe. The evolution of physical anthropology as a discipline is covered in detail from the 18th century onwards, and current trends in education and research are also discussed. Additional topics include a synthesis of the legislative framework for studying human skeletal remains in over 40 European countries while also addressing challenges, future trends and emerging ethical questions. This overview is the product of an extensive review of the literature partnered with information received via questionnaires completed by colleagues working in nearly 50 European countries. Copyright © 2016 John Wiley & Sons, Ltd.