This study investigates how employees' perceptions of adverse work conditions might discourage innovative behavior and the possible buffering roles of relational resources. Data from a Mexican‐based organization reveal that perceptions of work overload negatively affect innovative behavior, but this effect gets attenuated with greater knowledge sharing and interpersonal harmony. Further, although perceived organizational politics lead to lower innovative behavior when relational resources are low, they increase this behavior when resources are high. Organizations which seek to adopt innovative ideas in the presence of adverse work conditions thus should create relational conduits that can mitigate the associated stress.