Nowadays, low back pain becomes a common healthcare problem. Poor or unsuitable seat design is related to the discomfort and other healthcare problems of users. The aim of this study is to investigate the influence of seat design variables on the compressive loadings of lumbar joints. A basis that includes a musculoskeletal human body model and a chair model has been developed using LifeMOD Biomechanics Modeller. Inverse and forward dynamic simulations have been performed for various seat design parameters. The results show that the inclination of backrest and seat pan may or may not decrease the compressive spinal joint forces, depending on other conditions. The medium‐level height and depth of seat pan and the medium‐level and high‐level height of backrest are found to cause the minimum compressive loads on lumbar joints. This work contributes to a better understanding of sitting biomechanics and provides some useful guidelines for seat design.