This study aims to describe nurses’ knowledge of and attitudes towards the management of fever in one children’s hospital in Ireland. A descriptive, quantitative research design was employed. One hundred and nineteen nurses working in one children’s hospital completed a self-report questionnaire. Nurses’ mean knowledge score about the physiology of fever, fever management and antipyretics was 51 per cent (n = 119), which was lower than expected. Nurses had both appropriate and inappropriate attitudes towards fever and fever management. Inconsistent attitudes between nurses were identified. Nurses who participated in this study are not expert managers of fever. Their lack of knowledge and inconsistent attitudes are affecting the care of febrile children, and may be fuelling parents’ fever phobia. Further education is required to improve nurses’ knowledge of fever and fever management. Inappropriate attitudes need to be challenged and addressed in an effort to promote evidence-based care for febrile children.