In contrast with traditional considerations, sexuality is often perceived today as being rather compatible with religion/spirituality and morality. However, there may be some inherent opposition between (a) sexuality (thoughts, affects, and pleasure) and (b) religion/spirituality (attitudes, motives) and (interpersonal) morality (dispositions, behavior). The two imply, respectively, self‐enhancement versus self‐transcendence, disinhibition versus self‐control, and disgust indifference versus sensitivity. We hypothesized that sexual experience attenuates spiritual and moral concerns and behaviors. In three online experiments, young adults were asked to recall a personal sexual experience. Compared to a control condition, sexual induction diminished spiritual behavioral intentions (Experiments 1 and 2), in particular among those with high individual disinhibition (Experiment 1), as well as behaviors of prosociality and integrity/honesty (Experiment 3). The effects were independent of individual religiousness/spirituality. These findings suggest that combining sexual pleasure with self‐transcendence and moral perfection, even if a legitimate ideal, is not an easy enterprise.