According to the correlation between product quality and equipment degradation state, an equipment maintenance policy is designed by integrating periodic equipment inspection and product quality control. In this policy, np-chart is used to monitor the abnormal shift of the product quality characteristic based on periodic inspection of the equipment. By considering the inspection result of the product quality shift and equipment degradation state, the corresponding maintenance action is chosen. Furthermore, the optimal maintenance model based on product quality control is proposed and is solved with genetic algorithm. The experimental results validated the feasibility of this model.