Objective: Clinical considerations that can be culled from the intervention research presented in this special issue are summarized for practitioners treating violence-involved (i.e., perpetrators and victims of violence) populations. Clinical reflections are organized thematically, with studies grouped based on (a) unique settings for clinical care, (b) innovative methods for clinical care, (c) advanced assessments for monitoring clinical care, and (d) co-occurring conditions to address when providing clinical care. Key Points: Unique settings for clinical service delivery, including hospitals and schools, provide opportunities for multicomponent and multidisciplinary treatment of violence-involved individuals. Innovative methods for clinical care incorporate technological advances and pharmacology to move beyond traditional service delivery techniques. Advanced assessments for clinical work consider not just psychopathology, but also adaptive functioning and cognitive sequelae when conceptualizing individuals involved in violence. HIV is one of many conditions that commonly co-occur with violence; ways to incorporate sexual risk into violence treatment and vice versa are addressed. Implications: Clinicians can consider this summary of clinical takeaway points as a practical resource for treating violence-involved populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)