This study investigates the mediation impact of grade point average (GPA) and general health positive on Facebook addiction via self-esteem (SE) under the provision of active daily use of Facebook. We reached 120 participants who are college students. Our sample comprised 63 (52.5%) females and 57 (47.5%) males. We collected data through an online questionnaire. Structural equation modeling using IBM SPSS AMOS and mediation analysis were performed. The findings of the study suggested that SE is a critical and shaping construct when the decreasing impact of both GPA and general health positive on Facebook addiction is a concern. College students with low GPA and general health–positive feelings have low SE, which in turn increases the possibility of becoming a Facebook addict. Moreover, active daily use of Facebook is another factor triggering addiction. Recommendations and further research studies are presented.