Police response time to calls for service is a crucial factor in evaluation of police performance. While domestic violence is now considered serious interpersonal violence, factors associated with response time to domestic violence incidents are underexplored. Using hierarchical linear modeling, over 10,000 cases of calls for service for domestic violence across 438 census tracts in Houston, Texas, were examined. The result of multilevel analysis revealed that complainant’s race, weapon involvement, and day and time of incidents were associated with response time at the situational level. At the neighborhood level, concentrated disadvantage, immigration concentration, and residential stability were significantly associated with response time.