This clinical update review focuses on the classification and description of common neuropsychiatric manifestations in Parkinson’s disease (PD).

We conducted a systematic search of the literature using Pubmed and selected the most recent and relevant papers for this review.

Neuropsychiatric manifestations in PD are are very frequent and may arise from an abnormal psychopathological response to the disease, neurobiological changes related to the disease itself, complications of treatments or a combination of all of these.

Neuropsychiatric symptoms may precede the motor clinical presentation of PD. Early recognition is essential.